Medicinal Chemistry 1 Notes PDF Free

Hello in this blog post, I’ve provided an overview as well as download links for notes of Medicinal Chemistry 1(BP402T) according to the PCI syllabus for B Pharm 4th Semester 2023.

Overview

The notes in Medicinal Chemistry 1, we have provided two kinds of notes: Handwritten notes and Standard notes.

Medicinal Chemistry 1 notes are designed to provide fundamental information on the chemical structure and therapeutic properties of drugs. The topic focuses on the relationship between the structure and activity of drugs, the significance of physicochemical properties as well as the metabolic process of drugs. The syllabus also stresses an understanding of chemical syntheses for key drugs in each subject…

Friends Medicinal Chemistry 1 is the subject of the 4th semester of the B Pharm course, and as per the syllabus copy of PCI B Pharm 4th semester, there are a total of 5 units in this subject.

Read this: B Pharma 4th Semester all Study Material PDF Free

Download Medicinal Chemistry 1 All Units Notes PDFs FREE

Click on the following download buttons below the names of the units to download Medicinal Chemistry 1 both Handwritten and Standard Notes.

In the Medicinal Chemistry 1 Notes Pdfs, the following chapters are explained in detail.

UNIT-1

A brief introduction Medicinal Chemistry

History & development of medicinal chemistry.

Physicochemical properties of the biological actions

Ionization Solubility partition coefficient, hydrogen bonding Chelation, protein binding, Optical & Geometrical isomerism.

The principles of drug metabolism phase I & Phase II.

Drug metabolism is affected by stereochemical aspects.

UNIT-2

Drugs that affect the Autonomic Nervous system.

Neurotransmitters Biosynthesis & breakdown of catecholamine. Adrenergic receptors & their distribution.

Sympathomimetic agents- Sympathomimetic agents with direct action Nor-epinephrine Epinephrine, Phenylephrine, Dopamine, Methyldopa, Clonidine, Dobutamine Isoproterenol Terbutaline, & Salbutamol. Bitolterol Naphazoline Oxymetazoline & Xylometazoline. Indirectly active agents are Hydroxyamphetamine, Pseudoephedrine, and Propylhexedrine. Agents with a mixed mechanism Ephedrine, Metaraminol.

Adrenergic Antagonists:

Alpha-adrenergic blockers- Tolazoline, Phentolamine, Phenoxybenzamine, Prazosin, Dihydroergotamine, Methysergide. Blockers of

beta-adrenergic receptors- SAR beta-blockers Propranolol, Metibranolol, Atenolol, Betaxolol, Bisoprolol, Esmolol, Metoprolol, Labetalol, Carvedilol.

UNIT-3

Neurotransmitters of the Cholinergic family: biosynthesis & catabolism of Acetylcholine. Cholinergic receptors (Muscarinic & Nicotinic) & their distribution.

Parasympathomimetic agents: SAR Parasympathomimetic Agents

Direct-acting Agents: Acetylcholine, Carbachol, Bethanechol, Methacholine, Pilocarpine.

Indirect-acting inhibitors of Cholinesterase (Reversible & irreversible): Physostigmine, Neostigmine, Pyridostigmine, Edrophonium chloride, Tacrine hydrochloride, Ambenonium chloride Isofluorphate, Echothiophate iodide, Parathion, & Malathion.

Cholinesterase reactivator: Pralidoxime chloride.

SAR of cholinolytic substances Alkaloids with a solanaceous structure & analogs: Atropine sulfate, Hyoscyamine sulfate Scopolamine hydrobromide Homatropine hydrobromide Ipratropium bromide. Synthetic cholinergic blocking agents: Tropicamide, Cyclopentolate hydrochloride, Clidinium bromide Dicyclomine hydrochloride Glycopyrrolate, Methantheline bromide, Propantheline bromide Benztropine mesylate Orphenadrine citrate Biperidine hydrochloride Procyclidine hydrochloride Tridihexethyl chloride Isopropamide iodide Ethopropazine hydrochloride.

UNIT-4

Drugs that act upon Central Nervous System:

A. Sedatives & Hypnotics: Benzodiazepines, SARs of Benzodiazepines, Chlordiazepoxide, Diazepam, Oxazepam, Chlorazepate, Lorazepam, Zolpidem, Alprazolam. Barbiturates, SAR of barbiturates Phenobarbital, Barbital, Mephobarbital, & Amobarbital. Butabarbital & Pentobarbital. Secobarbital Other: Imides & imides Glutethmide. Alcohol & its carbamate derivatives Meprobomate, Ethchlorvynol. Aldehyde & its derivatives Triclofos sodium Paraldehyde.

B. Antipsychotics Phenothiazines: SAR of Phenothiazeines Promazine hydrochloride & Chlorpromazine hydrochloride, Triflupromazine, Thioridazine hydrochloride, Piperacetazine hydrochloride, Prochlorperazine maleate, Trifluoperazine hydrochloride. Ring Analogues to Phenothiazeines: Chlorprothixene, Thiothixene, Loxapine succinate, Clozapine. Fluro butyrophenones: Haloperidol, Droperidol, Risperidone. Beta amino ketones Molindone hydrochloride. Benzamides: Sulpieride.

C. Anticonvulsants SAR of Anticonvulsants mechanism of action of anticonvulsants Barbiturates Phenobarbitone, Metha barbital. Hydantoins Phenytoin, Mephenytoin, Etherton Oxazolidine dines: Trimethadione, Paramethadione Succinimides: Phasianidae, Ethosuximide, Ethosuximide Urea, & monocultures Phenacemide, Carbamazepine Benzodiazepines: Clonazepam Other: Primidone, Valproic acid, Gabapentin, Felbamate.

UNIT-5

Drugs that act on the Central Nervous System:

General anesthetics: Inhalation anesthetics Halothane, Methoxyflurane, Enflurane, Sevoflurane, Isoflurane, Desflurane. Barbiturates that have ultra-short-acting properties: Methohexital sodium, Thiamylal sodium, and Thiopental sodium. Dissociative anesthetics Ketamine hydrochloride. Analgesics for non-narcotic & narcotic use. Morphine & related drugs SARs of Morphine analogs, Morphine sulfate, Codeine, Meperidine hydrochloride, Anilerdine hydrochloride Diphenoxylate hydrochloride Loperamide hydrochloride Fentanyl citrate Methadone hydrochloride Propoxyphene hydrochloride Pentazocine Levorphanol tartrate.

Narcotic antagonists: Nalorphine hydrochloride, Levallorphan tartrate, Naloxone hydrochloride. Agents to reduce inflammation: Sodium salicylate, Aspirin, Mefenamic acid, Meclofenamate, Indomethacin, Sulindac, Tolmetin, Zomepriac, Diclofenac, Ketorolac, Ibuprofen, Naproxen, Piroxicam, Phenacetin, Acetaminophen, Antipyrine, Phenylbutazone.

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